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Injectable penicillin is the go-to treatment for syphilis and the only treatment considered safe for pregnant people with the disease.
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The shortage comes as there has been a steady increase in rates of syphilis since 2000. Inventory can start depleting as early as this month, Pfizer said.
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The medication is the only one available to prevent an infected pregnant woman from passing the disease to a fetus. Pfizer says the shortage should be over in July.