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First, can someone who has been vaccinated still spread the disease? Second, will the vaccine remain effective as the virus itself evolves? And third, how long will the vaccine's protection last?
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View NPR's maps and graphics to see where COVID-19 is hitting hardest in the U.S., which state outbreaks are growing and which are leveling off.
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President-elect Biden is sworn in this week, but his inauguration will look vastly different. U.S. is on the verge of 400,000 coronavirus deaths. A Putin critic is arrested after landing in Moscow.
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On Tuesday, it will be a year since the first case of COVID-19 was reported in the U.S. Now there are almost 24 million cases and nearly 400,000 people are dead.
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Many nations are betting on a vaccine made in China to immunize their populations. Clinical trial data from Brazil shows it is only 50% effective — less than the 78% previously reported.
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The anti-vaccine movement has existed in various forms for decades. The Internet and social media created a surge in misinformation. We profile a mother who got pulled in, and how she got out.
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When schools closed last spring, children with severe mental illnesses were cut off from the services they'd come to rely on. Many have since spiraled into emergency rooms and even police custody.
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Doctors are treating record numbers of stubbed, and often broken, toes as people spend more time shoeless at home.
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Los Angeles is transforming Dodger Stadium from a mass coronavirus testing site to a mass vaccination site. The city estimates it will be able to inoculate up to 12,000 people per day.
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A federal manufacturing contract to increase COVID-19 vaccine production has an unusual clause that could move a company's employees and their families to the front of the vaccination line.
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Millions of Americans either hesitate or don't want to get a COVID-19 vaccine. A recent measles outbreak in the Pacific Northwest offers lessons in convincing people to say "yes" to vaccination.
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Cheers erupted in hospital wards across the country as a first group of nurses and sanitation workers rolled up their sleeves and got vaccinated. India aims to inoculate 300 million by July.