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The health department sent "letters of intent" to the group, but the move sets up what could be lengthy litigation from applicants that missed out on a rare chance to join the state's medical pot industry.
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The ballot measure's defeat could strengthen the industry as it struggles to compete with hemp-based products sold at gas stations, CBD shops and online at a fraction of the cost.
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The cannabis company's latest $1.5 million contribution to Smart & Safe Florida provided the political committee a total of $152.27 million in cash and $959,000 in in-kind contributions.
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The Florida chapter of the American Academy of Pediatrics cites an increase in cases of emergency care among children since medical marijuana was approved in the state in 2016.
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In the past, Trulieve CEO Kim Rivers has tempered her public criticism of Gov. Ron DeSantis and his administration, which regulates her business. But she called DeSantis' critiques on Amendment 3 “hogwash.”
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As the campaign to get recreational marijuana in the state constitution goes into its final days, the cannabis company has funded more than $143 million of Smart & Safe Florida's war chest.
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Trulieve has largely bankrolled the Smart & Safe Florida political committee, which is leading efforts to pass the proposal, according to the state Division of Elections website.
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With recreational pot legal, patients will eventually need to decide if they want to keep their card, which costs $75 a year and requires doctor's visits every seven months costing between $350 and $600 a year.
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Amendment 3 could help end an era of discriminatory enforcement, according to some proponents, elected officials and drug experts. How and whether it will is a growing question.
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Trulieve has donated nearly $100 million to support Amendment 3. The state's Republican chair says the lawsuit is a result of the ads "working" and being "truthful."