ALS

On this episode, a panel of experts delves into the forefront of health care, dissecting the latest advancements and trends.

The FDA panel voted 17-1 that drugmaker Brainstorm’s stem cell-based treatment has not been shown effective for patients with amyotrophic lateral sclerosis. One panel member abstained from voting.

The agency reiterated its longstanding position that a lone study by drugmaker Brainstorm doesn't provide convincing evidence that its stem cell-based therapy helps patients with amyotrophic lateral sclerosis.

After Brian Wallach was diagnosed with ALS, he and his wife Sandra Abrevaya threw themselves into advocating for patients. Everyone up to President Biden took notice.

The approval came despite a drug-makers' study that failed to meet the company goal of significantly slowing ALS. The drug did make a difference on lab measures of the disease, but the FDA is requiring additional research.

Patients with insurance coverage say the cost set by drugmaker Amylyx Pharmaceutical is fueling insurance delays or denials, and sometimes exorbitant out-of-pocket expenses.

A controversial new drug for ALS could add months to patients' lives – if it actually works

In March, experts who advise the FDA questioned the efficacy of an experimental new drug for ALS. In September, they voted to approve it anyway.

The ruling is a remarkable turnaround for the much-debated medication that was previously rejected by the same group this year.

The vote by the agency's health advisers is a potential setback for patient groups who have lobbied for the medication’s approval for more than a year.