Built For Counterterrorism, This High-Tech Machine Is Now Helping Fight Fentanyl

Nov 27, 2019
Originally published on November 27, 2019 11:04 am

Sarah Mackin runs a cotton swab around the inside of a tiny plastic baggie that appears to be empty. She spreads whatever residue the swab picked up onto a test strip that resembles a Band-Aid, then slides the strip into a buzzing machine about the size of a boxed, take-home pie. Then she waits, hoping for information that she can share with Boston's community of opioid users.

Mackin is using an MX908, a mass spectrometer initially marketed as a counterterrorism tool. The machine can help military teams looking for traces from biological or chemical weapons, or hazardous material specialists trying to identify materials used in spills or explosions. But now the MX908 has been commandeered in the fight against fentanyl, one of Boston's — and the nation's — top killers.

The machine rapidly analyzes a sample of drugs, and can detect and identify dozens of types of fentanyl — a synthetic opioid which is fifty times more potent than heroin. Fentanyl is increasingly mixed with heroin and cocaine, often without the user's knowledge, and has become a major contributor to fatal drug overdoses in recent years.

It's too early to know how helpful the MX908 could be in lowering the mortality rate in the country's ongoing drug abuse epidemic. But that's why Mackin, the director of harm reduction services at the Boston Public Health Commission, is field-testing the machine.

Mackin looks down at a screen that spans the top of the MX908 and taps an icon labeled "drug hunter."

A swab is used to take an initial trace sample of the substance in the bag, prior to testing with the MX908.
Jesse Costa / WBUR

"This is something that was sold as heroin," Mackin says, dangling the baggie as the machine whirs through its cycle. The MX908 can identify 70 specific types of fentanyl in a tiny sample, and alert users about the presence of more than 2,000 not-yet-named fentanyl analogues.

It also detects the presence of MDMA, cocaine and meth — all based on tiny samples left at the tip of a needle, or even wiped onto a cotton ball. About 30 seconds after starting the test, Mackin watches red and yellow warning symbols flash across the screen.

"Oh yeah," Mackin says, nodding her head. "So, there's multiple kinds of opioid analgesics and multiple kinds of synthetic fentanyls in this sample that was sold as 'heroin.' It's kind of an example of what the drug landscape looks like here."

The illicit street drugs sold in Boston probably crossed international borders. They may have been cut and remixed multiple times as they moved along the supply chain. Drug users rarely know for sure what they are buying. Drug-testing devices like the MX908 can help identify additives that raise the risk of overdose.

Take the experience of a woman named Bri. (NPR is only using Bri's first name because she uses illegal drugs.) One day last July, Bri brought in residue from some of her drugs when the machine was set up in downtown Boston. On that day, she had three different samples. Bri had already overdosed on a hit from one of the bags.

"That's why I wanted it tested," Bri says. "I thought there was carfentanil in it."

Carfentanil, sometimes called the elephant tranquilizer, shows up in the Boston drug supply sporadically, along with other increasingly powerful and deadly forms of fentanyl.

In Bri's case, one of her samples showed no trace of drugs at all, one tested positive for a medical-grade fentanyl, and the third showed traces of a substance in the potency range of carfentanil.

The MX908 detects the possible presence of fentanyl in a drug sample.
Jesse Costa / WBUR

"Now, I'm going to be honest," Bri says. "If I was sick and I had one bag of dope on me and you told me there's carfentanil in there, I'm not going to lie and say I wouldn't use it. But I would know to not put the entire thing in."

Bri says she knows ingesting that particular sample would be a very risky move. But with that knowledge, there are steps she can take to reduce the risk of death: She can use the drugs in the presence of a buddy who can observe her for signs of overdose. Bri also carries around naloxone, a drug used to quickly reverse an opioid overdose.

These precautions can help Bri moderate her risk of overdose, and research shows that is one main way that drug testing saves lives — whether it's done through a machine like the MX908 or lower-tech methods like fentanyl test strips.

The value of drug-checking

Another way drug checking can save lives is by alerting local authorities, like the Boston Public Health Commission, that deadly concentrations of opioids have been found in the local drug supply.

It's complicated, however. Addiction is such a powerful disease that such warnings might actually serve as unwitting advertisements, alerting people who are seeking an ever-more powerful high.

But Traci Green, who is a researcher in emergency medicine at Rhode Island Hospital and Brown University, says her own research, as well as some European studies, show that drug-testing is ultimately beneficial: When drug users have the power to test what they buy, they seek out drug dealers with the safest supply.

"So this improvement in consumer knowledge and confidence in what they're getting, and how to use it, can improve the safety of the larger supply," Green says.

Green will evaluate this trial run of the MX908 in Boston. She says she's especially interested in learning whether its deployment can attract hard-to-reach drug users, the ones who traditionally avoid contact with any institutions or medical care. Access to the MX908 might bring them into a setting where they begin to interact with outreach workers, and possibly begin a conversation about treatment.

A steep price tag and legal issues

One other city, Chicago, is also testing the MX908 as a harm reduction tool for the opioid crisis. But there are reasons why it may not be more widely adopted. One is the price tag: $65,000.

In Boston, the city paid for the device through a grant from RIZE Massachusetts, a foundation focused on combating the opioid epidemic.

"Cost is one concern," says RIZE CEO Julie Burns. "But what is the value of a human life? If we decide through the evaluation that this is something that is reducing overdoses, I believe it is worth the investment."

Still, there are cheaper ways to find out if a drug baggie contains fentanyl.

Street outreach workers have been distributing fentanyl test strips, which cost about $1 apiece, for more than two years. The current Massachusetts state budget includes $150,000 to expand access to these test strips.

Like the MX908, the strips show the presence or absence of fentanyl — though the machine can offer much greater detail, as well as information about the presence of several types of stimulants. (Neither the machine nor the test strips can reveal how much fentanyl is in a baggie.)

A fentanyl test strip is used to detect fentanyl in a drug sample. Such test strips cost about $1 apiece.
Jesse Costa / WBUR

For now, harm reduction programs will have to decide which drug testing tool is most cost-effective, based on their goals and budget, says Greg Scott, who leads the Chicago Recovery Alliance, or CRA. The CRA began an extensive drug-checking program in March that includes two MX908s.

Scott says so far, the MX908 is delivering on two goals: helping people use drugs more safely and offering real-time information about the drug supply in Chicago. But Scott says unless drug checking becomes much more widespread, it won't force drug dealers and suppliers to "clean up" the drug supply.

"Getting to that scale and that level of impact is a very costly endeavor," Scott says.

Another reason public health workers may hesitate to use the MX908 is that doing so may be illegal in their jurisdiction.

"Drug checking is a legal gray area," says Northeastern University law professor Leo Beletsky. "There are provisions in Massachusetts law and the laws of pretty much every other state that might be interpreted to consider drug checking devices as 'drug paraphernalia.' "

That includes fentanyl test strips. Illinois enacted legislation in August that exempts people who test their drugs from prosecution. In Massachusetts, lawmakers are reviewing a proposal to make use of drug-checking tools legal.

Boston police say they aren't involved in the MX908 pilot and referred questions to the city's public health commission. The U.S. attorney's office in Massachusetts declined a request for their perspective on the use of this device for public health purposes.

The MX908 is also used in more traditional ways by police, fire and hazmat teams across Massachusetts. Even they have found that the leading enemy agent is fentanyl, says David DiGregorio, who directs the hazardous materials emergency response division at the Massachusetts Department of Fire Services. His department has about a dozen of the machines.

"If you had asked me if I was going to be involved in drugs five years ago I would have said, 'No, it's not my job.' It's become my job," DiGregorio says. "Hazmat calls are up in the last two years, exponentially, and a lot of that has to do with drug calls, because we can identify these powders in the field."


This story is part of a reporting partnership that includes WBUR, NPR and Kaiser Health News.

Copyright 2019 WBUR. To see more, visit WBUR.

STEVE INSKEEP, HOST:

A machine that's designed to help detect residue from chemical weapons has a new use in Boston where it can help prevent drug overdoses. The main culprit here is the powerful opioid fentanyl. Martha Bebinger of member station WBUR begins our story next to that buzzing machine and a tiny plastic baggie that appears empty.

(SOUNDBITE OF BUZZING)

SARAH MACKIN: This is something that was sold as heroin.

MARTHA BEBINGER, BYLINE: Sarah Mackin runs a Q-tip-type swab around the inside of this baggie, swipes whatever granules it found onto a test strip and slides the strip into this machine.

MACKIN: I'm going to go to the setting called drug hunter. I'm going to run it. It takes about 30 seconds.

BEBINGER: Meet the MX908. This mass spectrometer is about the size of a boxed take-home pie. It can identify 70 specific types of fentanyl, as well as meth and cocaine, based on virtually invisible traces, like what's left on the tip of a needle or wiped onto a cotton ball. Mackin, with the Boston Public Health Commission, watches red and yellow warning symbols flash across the machine's screen.

MACKIN: Oh, yeah. So there's multiple kinds of opioid analgesics and multiple kinds of synthetic fentanyls in this sample that was sold as heroin. It's kind of an example of what the drug landscape looks like here.

BEBINGER: Drugs for sale in the U.S. today cross borders and are cut and remixed many times. Drug users rarely know for sure what they are buying. Take the experience of a woman named Bri. We're only using Bri's first name because she uses illegal drugs. She brought in residue from three separate bags to have it tested by the machine on a downtown Boston street. One hit sent Bri into an overdose.

BRI: So that's why I wanted it tested. I wanted to know if - I thought there was carfentanil in it.

BEBINGER: Carfentanil, sometimes called the elephant tranquilizer, shows up sporadically in Boston. In Bri's case, one sample had no trace of any drugs, one had a medically approved form of fentanyl, and the third showed traces of something Bri learns is about as dangerous as carfentanil.

BRI: Now, I'm going to be honest. If I was sick and I had one bag of dope on me and you told me there's carfentanil in there, I'm not going to lie and say I wouldn't use it, but I would know to not put the entire thing in.

BEBINGER: Bri says she knows that would still be very risky. She tries to use with a buddy and makes sure she carries the overdose antidote naloxone. Testing the drug supply is called drug checking. Research shows it saves lives by reducing the risk of overdose. The testing also helps warn drug users and the Boston Public Health Commission.

BRI: So now they can tell people, hey, just to let you know, there's some really strong killer stuff that's coming out of, let's say, Copley.

BEBINGER: That kind of public warning could go either way. Some drug users say they might rush off to Copley Square to buy some. But Traci Green, an epidemiologist who studies drug checking at Rhode Island Hospital, says when drug users can test what they buy, they seek out dealers with the safest supply.

TRACI GREEN: So this improvement of consumer knowledge and confidence in what they're getting and how they might be able to use it can help us improve the safety of the larger supply.

BEBINGER: Only one other city - Chicago - is assessing the public health benefits of this device more typically used to detect chemical and biological weapons. But there are two reasons it may not be widely adopted for drug checking. One is the price tag - $65,000. The second - it may be illegal. Northeastern University law professor Leo Beletsky explains.

LEO BELETSKY: Drug checking is a legal gray area. There are provisions in Massachusetts law and the laws of pretty much every other state that might be interpreted to consider drug checking devices as drug paraphernalia.

BEBINGER: So use of the MX908 is proceeding cautiously in Boston. Massachusetts lawmakers are considering a bill that would make the MX908 and other drug checking tools legal. For NPR News, I'm Martha Bebinger in Boston. Transcript provided by NPR, Copyright NPR.