Carrying Some Extra Pounds May Not Be Good After All

Apr 3, 2017
Originally published on April 4, 2017 4:13 pm

New research published Monday adds fuel to an ongoing debate in the public health community over whether a few extra pounds are good, or bad, for you.

Earlier research found that being somewhat overweight, but not obese, may result in a longer life.

But today's study in the Annals of Internal Medicine suggests that being slightly overweight may actually decrease a person's life span, which is more in line with conventional wisdom about weight.

So who's right? It's all about study design and statistical analysis.

Let's start with the newest study, headed by demographer Andrew Stokes at Boston University School of Public Health. His group found a 6 percent increased risk of dying from any cause among individuals with a history of being overweight.

Although Stokes says that 6 percent "is only a modest increase," it's still "extremely worrisome" because so many Americans are overweight.

"Our findings confirm that there is no benefit of being overweight on risk of death, and indicate that [being] overweight is actually associated with an increased risk of dying," he says.

These findings apply only to those who are overweight, not to obese people. There is little debate that people who are obese are at increased risk for diabetes, heart disease, certain cancers and even premature death.

Overweight is defined as a body mass index, or BMI, of 25 to 29.9, which is about ten to 30 pounds overweight depending on your height. Obese is defined as anyone with a BMI of 30 or above. You can calculate your BMI here.

About 38 percent of Americans over 20 years old are considered overweight, according to the Centers for Disease Control and Prevention. Another 30 percent or so fall into the obese category.

For their study, Stokes and colleagues gathered data on more than 225,000 adults over the age of 50 to determine whether being overweight affected life span. They included people participating in three major studies that lasted between eight and 20 years.

Stokes focused on each person's maximum BMI over a 16-year period, which he says makes the findings more reliable than earlier studies that have used a single BMI without regard to whether someone is gaining or losing weight at the time of the measurement.

Stokes's study was also more likely to exclude people who had temporarily lost weight due to illness.

His approach is different from that taken by the authors of the 2013 study that startled many in the public health community by suggesting that being overweight could lead to a longer life.

In that study, CDC epidemiologist Katherine Flegal and her colleagues analyzed results from 97 studies of obesity, covering nearly 3 million people, and found that the combined effect showed "a slight decrease in mortality" among overweight individuals, when compared to those of normal weight.

It was surprising news.

"Our article got called rubbish and ludicrous," Flegal told NPR in 2013, "so it really opens you to lots of criticism. I discovered, much to my sorrow, that this is kind of a flashpoint for people."

Flegal continues to stand by her results, and she criticized the new study for relying on people's memories of their own weight.

"We know people don't report their weight and height very accurately. Women tend to under report weight and men tend to over report height," Flegal, now of Stanford University, says.

She also says that her findings were more accurate than the new study's findings because her work was not based on participants' maximum weight, which might make them appear less healthy.

But Stokes says Flegal's study is "seriously flawed" because it fails to separate the effects of illness on weight from the effect of weight on risk of disease. "This new analysis provides a novel way of addressing this issue by using weight history to distinguish between people who were slim over time from those who were formerly heavy and lost weight after developing an illness," he says.

Meanwhile, it's not clear why being overweight would be protective or even life-extending. Some researchers speculate it could be that a little extra fat protects people if they fall, or that it offers an energy reserve during illness.

Faced with these conflicting findings, Dr. Steven Heymsfield says people who are overweight should check with their doctor to see if they have other weight-related health problems such as high blood pressure, blood sugar or cholesterol. Heymsfield is an obesity researcher at the Pennington Biomedical Research Center at Louisiana State University in Baton Rouge, La.

For people who do have those problems, there are generally effective treatments available for the conditions. At the same time, he says, people should work to prevent future weight gain and, if possible, lose weight and try to bring their BMI down to a healthier level.

Stokes says future research should look at whether overweight people who diet, exercise and lose weight can turn back their risk of disease to that of an individual who never gained weight in the first place.

"Individuals should try as hard as possible to maintain weight in a normal range for as large a portion of their adult life as possible," he says.

Copyright 2017 NPR. To see more, visit http://www.npr.org/.

KELLY MCEVERS, HOST:

The dangers of obesity are well known. The dangers of carrying a little extra weight, though, are the subject of more debate. NPR's Patti Neighmond reports that a new study published this week in the Annals of Internal Medicine says being slightly overweight could actually shorten lifespan.

PATTI NEIGHMOND, BYLINE: Nobody's arguing about the dangers of obesity, which increases risk for diabetes, heart disease, certain cancers and even premature death. The debate here is about people who are overweight, but not obese. And that's a lot of people, says Dr. Steven Heymsfield, an obesity researcher at the Pennington Biomedical Research Center in Baton Rouge.

STEVEN HEYMSFIELD: People who are overweight generally know it. Their belt's a little tight. Their clothes don't fit as well as they used to. And I think most people who fall within that range have a pretty good sense that they're a few pounds overweight, but they're not quite obese.

NEIGHMOND: A body mass index, or BMI, over 25 is considered overweight. About one-third of Americans are overweight. Another 40 percent are considered obese. In the study, researchers looked at information gathered on more than 225,000 adults over 50. They wanted to know if being overweight affected lifespan. Demographer Andrew Stokes at Boston University School of Public Health headed the study, which found, yes, it did. There was a 6 percent increased risk of death among individuals who were overweight.

ANDREW STOKES: For this group, we found consistently across the board for all the causes of death examined that having a history of overweight over the 16-year period was associated with increased risk of death.

NEIGHMOND: Six percent is only a modest increase, he says, but it's worrisome because so many Americans are overweight. Now, the findings are also provocative because they seem to contradict earlier research published four years ago by Stanford University epidemiologist Katherine Flegal. At the time of her study, she was with the CDC.

KATHERINE FLEGAL: In our meta-analysis, we had 97 studies. And the combined effect of all those studies was to show a slight decrease in mortality in the overweight category relative to the normal weight category.

NEIGHMOND: So being overweight seemed to be protective. It's not clear why. Some doctors speculate it could be a little extra fat protects people if they fall or offers an energy reserve during illness. Researcher Stokes says his findings of increased risk of death among overweight people are more reliable because they examined weight over 16 years. And he says that makes the take-home message pretty clear.

STOKES: Individuals should try as hard as possible to maintain a weight in the normal range for as large a portion of their adult life as possible.

NEIGHMOND: Stokes says future research should look at whether an overweight person who diets, exercises and loses weight can turn back their risk of disease to that of an individual who never gained weight in the first place. In the midst of conflicting findings, researchers Steven Heymsfield says people who are overweight should check with their doctor to see if they have other weight-related health problems.

HEYMSFIELD: For example, is your blood sugar high? Is your blood pressure high? Is your cholesterol too high? If so, then you should consider treatment for those risk factors...

NEIGHMOND: ...Which all have effective treatments. At the same time, Heymsfield says, people should work hard to prevent future weight gain and, if so motivated, lose weight and try to bring their BMI down to a healthier level. Patty Neighmond, NPR News.

(SOUNDBITE OF IKEBE SHAKEDOWN SONG, "BY HOOK OR BY CROOK") Transcript provided by NPR, Copyright NPR.